You can now onboard Microsoft Defender for Endpoint (MDE) tenants in GCC High environments.
Once you follow the setup steps in KB article, your login, Graph, and MDE API traffic will automatically route to the correct GCC High .us endpoints.
This brings MDE in line with our existing GCC High support for ITDR, so if you've already mapped a GCC High tenant in ITDR, you can now onboard that same tenant into MDE